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The use of lisuride in the treatment of multiple system atrophy with autonomic failure (Shy-Drager syndrome).

机译：利舒利特在治疗具有自主神经功能衰竭的多系统萎缩中的应用（Shy-Drager综合征）。

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摘要

In a controlled trial lisuride, an ergolene derivative with dopamine receptor agonist properties was given maximum tolerated doses (2.4 mg/day) to seven patients with multiple system atrophy with autonomic failure (Shy-Drager syndrome). Improvement in Parkinsonian features occurred in only one patient and another patient who had been deriving marked benefit from levodopa treatment before the study began failed to respond to large doses of lisuride. Psychiatric side effects (including nightmares, isolated visual hallucinations and toxic confusional states) were the dose-limiting factor in six patients. A modest reduction in orthostatic hypotension occurred in two patients, one of whom had experienced an aggravation of this disturbance on levodopa and bromocriptine. Destruction of post-synaptic dopamine receptors and damage to central noradrenergic systems may offer an explanation for the lack of therapeutic effect of lisuride.

机译：在一项有对照的试验性乙草胺中，对具有多巴胺受体激动剂特性的麦角灵衍生物给予7名患有系统衰竭（Shy-Drager综合征）的多系统萎缩患者最大耐受剂量（2.4 mg /天）。帕金森病特征的改善仅发生于一名患者，而另一名在研究开始前已从左旋多巴治疗中获得显着益处的患者未能对大剂量利苏利特产生反应。精神病学副作用（包括噩梦，孤立的幻觉和有毒的精神错乱状态）是6例患者的剂量限制因素。两名患者的体位性低血压适度降低，其中一名患者对左旋多巴和溴隐亭的干扰加剧。突触后多巴胺受体的破坏和中枢去甲肾上腺素能系统的损伤可能为利苏立德缺乏治疗效果提供了解释。

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Lees, A J; Bannister, R;
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年度 1981
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正文语种 en
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专利

1. Cerebral blood flow and metabolism in multiple system atrophy of the Shy-Drager syndrome type: a PET study. [J] . Ogawa M, Fukuyama H, Harada K, Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology . 1998,第2期

机译：Shy-Drager综合征类型的多系统萎缩中的脑血流和代谢：一项PET研究。
2. Skin vasomotor reflex responses in two contrasting groups of autonomic failure : Multiple system atrophy and pure autonomic failure. [J] . Young TM, Asahina M, Nicotra A, Journal of neurology . 2006,第7期

机译：两种相对立的自主神经功能衰竭组的皮肤血管舒缩反射反应：多系统萎缩和单纯自主神经功能衰竭。
3. Hemodynamic effects of clonidine in two contrasting models of autonomic failure: multiple system atrophy and pure autonomic failure. [J] . Young TM, Asahina M, Watson L, Movement disorders . 2006,第5期

机译：可乐定在两种自主神经功能衰竭模型的血流动力学效应中：多系统萎缩和单纯自主神经功能衰竭。
4. 3-D Analysis of Cortical Morphometry in Differential Diagnosis of Parkinson's Plus Syndromes: Mapping Frontal Lobe Cortical Atrophy in Progressive Supranuclear Palsy Patients [C] . Duygu Tosun, Simon Duchesne, Yan Rolland, International Conference on Medical Image Computing and Computer-Assisted Intervention(MICCAI 2007) pt.2; 20071029-1102; Brisbane(AU) . 2007

机译：皮层形态计量学在帕金森氏综合症鉴别诊断中的3-D分析：进行性核上性麻痹患者额叶皮层萎缩的定位
5. Postprandial hypotension: hemodynamic differences between multiple system atrophy and peripheral autonomic neuropathy [D] . Hirayama M, Watanabe H, Koike Y, 1993

机译：餐后低血压：多系统萎缩与周围自主神经病变之间的血流动力学差异
6. The use of lisuride in the treatment of multiple system atrophy with autonomic failure (Shy-Drager syndrome). [O] . A J Lees, R Bannister 1981

机译：利舒利特在治疗具有自主神经功能衰竭的多系统萎缩中的应用（Shy-Drager综合征）。
7. Brain stem auditory evoked potentials in patients with multiple system atrophy with progressive autonomic failure (Shy-Drager syndrome). [O] . Prasher, D, Bannister, R 1986

机译：具有进行性自主神经功能衰竭（Shy-Drager综合征）的多系统萎缩患者的脑干听觉诱发电位。

The use of lisuride in the treatment of multiple system atrophy with autonomic failure (Shy-Drager syndrome).

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